TY  - JOUR
A1  - Ling, Hui
A1  - Spizzo, Riccardo
A1  - Atlasi, Yaser
A1  - Nicoloso, Milena
A1  - Shimizu, Masayoshi
A1  - Redis, Roxana S.
A1  - Nishida, Naohiro
A1  - Gafà, Roberta
A1  - Song, Jian
A1  - Guo, Zhiyi
A1  - Ivan, Cristina
A1  - Barbarotto, Elisa
A1  - De Vries, Ingrid
A1  - Zhang, Xinna
A1  - Ferracin, Manuela
A1  - Churchman, Mike
A1  - van Galen, Janneke F.
A1  - Beverloo, Berna H.
A1  - Shariati, Maryam
A1  - Haderk, Franziska
A1  - Estecio, Marcos R.
A1  - Garcia-Manero, Guillermo
A1  - Patijn, Gijs A.
A1  - Gotley, David C.
A1  - Bhardwaj, Vikas
A1  - Shureiqi, Imad
A1  - Sen, Subrata
A1  - Multani, Asha S.
A1  - Welsh, James
A1  - Yamamoto, Ken
A1  - Taniguchi, Itsuki
A1  - Song, Min-Ae
A1  - Gallinger, Steven
A1  - Casey, Graham
A1  - Thibodeau, Stephen N.
A1  - Le Marchand, Loïc
A1  - Tiirikainen, Maarit
A1  - Mani, Sendurai A.
A1  - Zhang, Wei
A1  - Davuluri, Ramana V.
A1  - Mimori, Koshi
A1  - Mori, Masaki
A1  - Sieuwerts, Anieta M.
A1  - Martens, John W.M.
A1  - Tomlinson, Ian
A1  - Negrini, Massimo
A1  - Berindan-Neagoe, Ioana
A1  - Foekens, John A.
A1  - Hamilton, Stanley R.
A1  - Lanza, Giovanni
A1  - Kopetz, Scott
A1  - Fodde, Riccardo
A1  - Calin, George A.
T1  - CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer
Y1  - 2013/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1446 
EP  - 1461 
DO  - 10.1101/gr.152942.112 
VL  - 23 
IS  - 9 
UR  - http://genome.cshlp.org/content/23/9/1446.abstract 
N2  - The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (lncRNA) encompassing the rs6983267 SNP, is highly overexpressed in microsatellite-stable colorectal cancer and promotes tumor growth, metastasis, and chromosomal instability. We demonstrate that MYC, miR–17–5p, and miR–20a are up-regulated by CCAT2 through TCF7L2-mediated transcriptional regulation. We further identify the physical interaction between CCAT2 and TCF7L2 resulting in an enhancement of WNT signaling activity. We show that CCAT2 is itself a WNT downstream target, which suggests the existence of a feedback loop. Finally, we demonstrate that the SNP status affects CCAT2 expression and the risk allele G produces more CCAT2 transcript. Our results support a new mechanism of MYC and WNT regulation by the novel lncRNA CCAT2 in colorectal cancer pathogenesis, and provide an alternative explanation of the SNP-conferred cancer risk. 
ER  -