@article{Kan01092013,
author = {Kan, Zhengyan and Zheng, Hancheng and Liu, Xiao and Li, Shuyu and Barber, Thomas D. and Gong, Zhuolin and Gao, Huan and Hao, Ke and Willard, Melinda D. and Xu, Jiangchun and Hauptschein, Robert and Rejto, Paul A. and Fernandez, Julio and Wang, Guan and Zhang, Qinghui and Wang, Bo and Chen, Ronghua and Wang, Jian and Lee, Nikki P. and Zhou, Wei and Lin, Zhao and Peng, Zhiyu and Yi, Kang and Chen, Shengpei and Li, Lin and Fan, Xiaomei and Yang, Jie and Ye, Rui and Ju, Jia and Wang, Kai and Estrella, Heather and Deng, Shibing and Wei, Ping and Qiu, Ming and Wulur, Isabella H. and Liu, Jiangang and Ehsani, Mariam E. and Zhang, Chunsheng and Loboda, Andrey and Sung, Wing Kin and Aggarwal, Amit and Poon, Ronnie T. and Fan, Sheung Tat and Wang, Jun and Hardwick, James and Reinhard, Christoph and Dai, Hongyue and Li, Yingrui and Luk, John M. and Mao, Mao}, 
title = {Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma},
volume = {23}, 
number = {9}, 
pages = {1422-1433}, 
year = {2013}, 
doi = {10.1101/gr.154492.113}, 
abstract ={Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet the molecular basis of hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study of 88 matched HCC tumor/normal pairs, 81 of which are Hepatitis B virus (HBV) positive, seeking to identify genetically altered genes and pathways implicated in HBV-associated HCC. We find beta-catenin to be the most frequently mutated oncogene (15.9%) and TP53 the most frequently mutated tumor suppressor (35.2%). The Wnt/beta-catenin and JAK/STAT pathways, altered in 62.5% and 45.5% of cases, respectively, are likely to act as two major oncogenic drivers in HCC. This study also identifies several prevalent and potentially actionable mutations, including activating mutations of Janus kinase 1 (JAK1), in 9.1% of patients and provides a path toward therapeutic intervention of the disease.}, 
URL = {http://genome.cshlp.org/content/23/9/1422.abstract}, 
eprint = {http://genome.cshlp.org/content/23/9/1422.full.pdf+html}, 
journal = {Genome Research} 
}