RT Journal
A1 Yoon, Kwiyeom
A1 Lee, Sunghoon
A1 Han, Tae-Su
A1 Moon, So Yeon
A1 Yun, Sun Mi
A1 Kong, Seong-Ho
A1 Jho, Sungwoong
A1 Choe, Jinny
A1 Yu, Jieun
A1 Lee, Hyuk-Joon
A1 Park, Ji Hyun
A1 Kim, Hak-Min
A1 Lee, So Yeun
A1 Park, Jongsun
A1 Kim, Woo-Ho
A1 Bhak, Jong
A1 Yang, Han-Kwang
A1 Kim, Seong-Jin
T1 Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers
JF Genome Research 
JO Genome Research 
YR 2013 
FD July 01 
VO 23 
IS 7 
SP 1109 
OP 1117 
DO 10.1101/gr.145706.112 
UL http://genome.cshlp.org/content/23/7/1109.abstract 
AB Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissues. We identified 18,377 MS mutations of five or more repeat nucleotides in coding sequences and untranslated regions of genes, and discovered 139 individual genes whose expression was down-regulated in association with UTR MS mutation. In addition, we found that 90.5% of MS mutations with deletions in gene regions occurred in UTRs. This analysis emphasizes the genetic diversity of MSI-H gastric tumors and provides clues to the mechanistic basis of instability in microsatellite unstable gastric cancers.