TY  - JOUR
A1  - Yoon, Kwiyeom
A1  - Lee, Sunghoon
A1  - Han, Tae-Su
A1  - Moon, So Yeon
A1  - Yun, Sun Mi
A1  - Kong, Seong-Ho
A1  - Jho, Sungwoong
A1  - Choe, Jinny
A1  - Yu, Jieun
A1  - Lee, Hyuk-Joon
A1  - Park, Ji Hyun
A1  - Kim, Hak-Min
A1  - Lee, So Yeun
A1  - Park, Jongsun
A1  - Kim, Woo-Ho
A1  - Bhak, Jong
A1  - Yang, Han-Kwang
A1  - Kim, Seong-Jin
T1  - Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers
Y1  - 2013/07/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1109 
EP  - 1117 
DO  - 10.1101/gr.145706.112 
VL  - 23 
IS  - 7 
UR  - http://genome.cshlp.org/content/23/7/1109.abstract 
N2  - Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissues. We identified 18,377 MS mutations of five or more repeat nucleotides in coding sequences and untranslated regions of genes, and discovered 139 individual genes whose expression was down-regulated in association with UTR MS mutation. In addition, we found that 90.5% of MS mutations with deletions in gene regions occurred in UTRs. This analysis emphasizes the genetic diversity of MSI-H gastric tumors and provides clues to the mechanistic basis of instability in microsatellite unstable gastric cancers. 
ER  -