RT Journal
A1 Wheeler, David A.
A1 Wang, Linghua
T1 From human genome to cancer genome: The first decade
JF Genome Research 
JO Genome Research 
YR 2013 
FD July 01 
VO 23 
IS 7 
SP 1054 
OP 1062 
DO 10.1101/gr.157602.113 
UL http://genome.cshlp.org/content/23/7/1054.abstract 
AB The realization that cancer progression required the participation of cellular genes provided one of several key rationales, in 1986, for embarking on the human genome project. Only with a reference genome sequence could the full spectrum of somatic changes leading to cancer be understood. Since its completion in 2003, the human reference genome sequence has fulfilled its promise as a foundational tool to illuminate the pathogenesis of cancer. Herein, we review the key historical milestones in cancer genomics since the completion of the genome, and some of the novel discoveries that are shaping our current understanding of cancer.