@article{Michaud01062013,
author = {Michaud, Joëlle and Praz, Viviane and James Faresse, Nicole and JnBaptiste, Courtney K. and Tyagi, Shweta and Schütz, Frédéric and Herr, Winship}, 
title = {HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy},
volume = {23}, 
number = {6}, 
pages = {907-916}, 
year = {2013}, 
doi = {10.1101/gr.150078.112}, 
abstract ={In human transcriptional regulation, DNA-sequence-specific factors can associate with intermediaries that orchestrate interactions with a diverse set of chromatin-modifying enzymes. One such intermediary is HCFC1 (also known as HCF-1). HCFC1, first identified in herpes simplex virus transcription, has a poorly defined role in cellular transcriptional regulation. We show here that, in HeLa cells, HCFC1 is observed bound to 5400 generally active CpG-island promoters. Examination of the DNA sequences underlying the HCFC1-binding sites revealed three sequence motifs associated with the binding of (1) ZNF143 and THAP11 (also known as Ronin), (2) GABP, and (3) YY1 sequence-specific transcription factors. Subsequent analysis revealed colocalization of HCFC1 with these four transcription factors at ∼90% of the 5400 HCFC1-bound promoters. These studies suggest that a relatively small number of transcription factors play a major role in HeLa-cell transcriptional regulation in association with HCFC1.}, 
URL = {http://genome.cshlp.org/content/23/6/907.abstract}, 
eprint = {http://genome.cshlp.org/content/23/6/907.full.pdf+html}, 
journal = {Genome Research} 
}