RT Journal
A1 Schmitz, Robert J.
A1 He, Yupeng
A1 Valdés-López, Oswaldo
A1 Khan, Saad M.
A1 Joshi, Trupti
A1 Urich, Mark A.
A1 Nery, Joseph R.
A1 Diers, Brian
A1 Xu, Dong
A1 Stacey, Gary
A1 Ecker, Joseph R.
T1 Epigenome-wide inheritance of cytosine methylation variants in a recombinant inbred population
JF Genome Research 
JO Genome Research 
YR 2013 
FD October 01 
VO 23 
IS 10 
SP 1663 
OP 1674 
DO 10.1101/gr.152538.112 
UL http://genome.cshlp.org/content/23/10/1663.abstract 
AB Cytosine DNA methylation is one avenue for passing information through cell divisions. Here, we present epigenomic analyses of soybean recombinant inbred lines (RILs) and their parents. Identification of differentially methylated regions (DMRs) revealed that DMRs mostly cosegregated with the genotype from which they were derived, but examples of the uncoupling of genotype and epigenotype were identified. Linkage mapping of methylation states assessed from whole-genome bisulfite sequencing of 83 RILs uncovered widespread evidence for local methylQTL. This epigenomics approach provides a comprehensive study of the patterns and heritability of methylation variants in a complex genetic population over multiple generations, paving the way for understanding how methylation variants contribute to phenotypic variation.