@article{Kostic01022012,
author = {Kostic, Aleksandar D. and Gevers, Dirk and Pedamallu, Chandra Sekhar and Michaud, Monia and Duke, Fujiko and Earl, Ashlee M. and Ojesina, Akinyemi I. and Jung, Joonil and Bass, Adam J. and Tabernero, Josep and Baselga, José and Liu, Chen and Shivdasani, Ramesh A. and Ogino, Shuji and Birren, Bruce W. and Huttenhower, Curtis and Garrett, Wendy S. and Meyerson, Matthew}, 
title = {Genomic analysis identifies association of Fusobacterium with colorectal carcinoma},
volume = {22}, 
number = {2}, 
pages = {292-298}, 
year = {2012}, 
doi = {10.1101/gr.126573.111}, 
abstract ={The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to carcinogenesis; however, the role of the microbiota is the least well understood. We have characterized the composition of the microbiota in colorectal carcinoma using whole genome sequences from nine tumor/normal pairs. Fusobacterium sequences were enriched in carcinomas, confirmed by quantitative PCR and 16S rDNA sequence analysis of 95 carcinoma/normal DNA pairs, while the Bacteroidetes and Firmicutes phyla were depleted in tumors. Fusobacteria were also visualized within colorectal tumors using FISH. These findings reveal alterations in the colorectal cancer microbiota; however, the precise role of Fusobacteria in colorectal carcinoma pathogenesis requires further investigation.}, 
URL = {http://genome.cshlp.org/content/22/2/292.abstract}, 
eprint = {http://genome.cshlp.org/content/22/2/292.full.pdf+html}, 
journal = {Genome Research} 
}