TY  - JOUR
A1  - Robinson, Mark D.
A1  - Strbenac, Dario
A1  - Stirzaker, Clare
A1  - Statham, Aaron L.
A1  - Song, Jenny
A1  - Speed, Terence P.
A1  - Clark, Susan J.
T1  - Copy-number-aware differential analysis of quantitative DNA sequencing data
Y1  - 2012/12/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 2489 
EP  - 2496 
DO  - 10.1101/gr.139055.112 
VL  - 22 
IS  - 12 
UR  - http://genome.cshlp.org/content/22/12/2489.abstract 
N2  - Developments in microarray and high-throughput sequencing (HTS) technologies have resulted in a rapid expansion of research into epigenomic changes that occur in normal development and in the progression of disease, such as cancer. Not surprisingly, copy number variation (CNV) has a direct effect on HTS read densities and can therefore bias differential detection results. We have developed a flexible approach called ABCD-DNA (affinity-based copy-number-aware differential quantitative DNA sequencing analyses) that integrates CNV and other systematic factors directly into the differential enrichment engine. 
ER  -