RT Journal
A1 Nielsen, Cydney B.
A1 Younesy, Hamid
A1 O'Geen, Henriette
A1 Xu, Xiaoqin
A1 Jackson, Andrew R.
A1 Milosavljevic, Aleksandar
A1 Wang, Ting
A1 Costello, Joseph F.
A1 Hirst, Martin
A1 Farnham, Peggy J.
A1 Jones, Steven J.M.
T1 Spark: A navigational paradigm for genomic data exploration
JF Genome Research 
JO Genome Research 
YR 2012 
FD November 01 
VO 22 
IS 11 
SP 2262 
OP 2269 
DO 10.1101/gr.140665.112 
UL http://genome.cshlp.org/content/22/11/2262.abstract 
AB Biologists possess the detailed knowledge critical for extracting biological insight from genome-wide data resources, and yet they are increasingly faced with nontrivial computational analysis challenges posed by genome-scale methodologies. To lower this computational barrier, particularly in the early data exploration phases, we have developed an interactive pattern discovery and visualization approach, Spark, designed with epigenomic data in mind. Here we demonstrate Spark's ability to reveal both known and novel epigenetic signatures, including a previously unappreciated binding association between the YY1 transcription factor and the corepressor CTBP2 in human embryonic stem cells.