TY  - JOUR
A1  - Nielsen, Cydney B.
A1  - Younesy, Hamid
A1  - O'Geen, Henriette
A1  - Xu, Xiaoqin
A1  - Jackson, Andrew R.
A1  - Milosavljevic, Aleksandar
A1  - Wang, Ting
A1  - Costello, Joseph F.
A1  - Hirst, Martin
A1  - Farnham, Peggy J.
A1  - Jones, Steven J.M.
T1  - Spark: A navigational paradigm for genomic data exploration
Y1  - 2012/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 2262 
EP  - 2269 
DO  - 10.1101/gr.140665.112 
VL  - 22 
IS  - 11 
UR  - http://genome.cshlp.org/content/22/11/2262.abstract 
N2  - Biologists possess the detailed knowledge critical for extracting biological insight from genome-wide data resources, and yet they are increasingly faced with nontrivial computational analysis challenges posed by genome-scale methodologies. To lower this computational barrier, particularly in the early data exploration phases, we have developed an interactive pattern discovery and visualization approach, Spark, designed with epigenomic data in mind. Here we demonstrate Spark's ability to reveal both known and novel epigenetic signatures, including a previously unappreciated binding association between the YY1 transcription factor and the corepressor CTBP2 in human embryonic stem cells. 
ER  -