TY  - JOUR
A1  - vonHoldt, Bridgett M.
A1  - Pollinger, John P.
A1  - Earl, Dent A.
A1  - Knowles, James C.
A1  - Boyko, Adam R.
A1  - Parker, Heidi
A1  - Geffen, Eli
A1  - Pilot, Malgorzata
A1  - Jedrzejewski, Wlodzimierz
A1  - Jedrzejewska, Bogumila
A1  - Sidorovich, Vadim
A1  - Greco, Claudia
A1  - Randi, Ettore
A1  - Musiani, Marco
A1  - Kays, Roland
A1  - Bustamante, Carlos D.
A1  - Ostrander, Elaine A.
A1  - Novembre, John
A1  - Wayne, Robert K.
T1  - A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids
Y1  - 2011/08/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1294 
EP  - 1305 
DO  - 10.1101/gr.116301.110 
VL  - 21 
IS  - 8 
UR  - http://genome.cshlp.org/content/21/8/1294.abstract 
N2  - High-throughput genotyping technologies developed for model species can potentially increase the resolution of demographic history and ancestry in wild relatives. We use a SNP genotyping microarray developed for the domestic dog to assay variation in over 48K loci in wolf-like species worldwide. Despite the high mobility of these large carnivores, we find distinct hierarchical population units within gray wolves and coyotes that correspond with geographic and ecologic differences among populations. Further, we test controversial theories about the ancestry of the Great Lakes wolf and red wolf using an analysis of haplotype blocks across all 38 canid autosomes. We find that these enigmatic canids are highly admixed varieties derived from gray wolves and coyotes, respectively. This divergent genomic history suggests that they do not have a shared recent ancestry as proposed by previous researchers. Interspecific hybridization, as well as the process of evolutionary divergence, may be responsible for the observed phenotypic distinction of both forms. Such admixture complicates decisions regarding endangered species restoration and protection. 
ER  -