@article{Drew01112011,
author = {Drew, Kevin and Winters, Patrick and Butterfoss, Glenn L. and Berstis, Viktors and Uplinger, Keith and Armstrong, Jonathan and Riffle, Michael and Schweighofer, Erik and Bovermann, Bill and Goodlett, David R. and Davis, Trisha N. and Shasha, Dennis and Malmström, Lars and Bonneau, Richard}, 
title = {The Proteome Folding Project: Proteome-scale prediction of structure and function},
volume = {21}, 
number = {11}, 
pages = {1981-1994}, 
year = {2011}, 
doi = {10.1101/gr.121475.111}, 
abstract ={The incompleteness of proteome structure and function annotation is a critical problem for biologists and, in particular, severely limits interpretation of high-throughput and next-generation experiments. We have developed a proteome annotation pipeline based on structure prediction, where function and structure annotations are generated using an integration of sequence comparison, fold recognition, and grid-computing-enabled de novo structure prediction. We predict protein domain boundaries and three-dimensional (3D) structures for protein domains from 94 genomes (including human, Arabidopsis, rice, mouse, fly, yeast, Escherichia coli, and worm). De novo structure predictions were distributed on a grid of more than 1.5 million CPUs worldwide (World Community Grid). We generated significant numbers of new confident fold annotations (9% of domains that are otherwise unannotated in these genomes). We demonstrate that predicted structures can be combined with annotations from the Gene Ontology database to predict new and more specific molecular functions.}, 
URL = {http://genome.cshlp.org/content/21/11/1981.abstract}, 
eprint = {http://genome.cshlp.org/content/21/11/1981.full.pdf+html}, 
journal = {Genome Research} 
}