TY  - JOUR
A1  - Hu, Gangqing
A1  - Schones, Dustin E.
A1  - Cui, Kairong
A1  - Ybarra, River
A1  - Northrup, Daniel
A1  - Tang, Qingsong
A1  - Gattinoni, Luca
A1  - Restifo, Nicholas P.
A1  - Huang, Suming
A1  - Zhao, Keji
T1  - Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1
Y1  - 2011/10/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1650 
EP  - 1658 
DO  - 10.1101/gr.121145.111 
VL  - 21 
IS  - 10 
UR  - http://genome.cshlp.org/content/21/10/1650.abstract 
N2  - Enhancers of transcription activate transcription via binding of sequence-specific transcription factors to their target sites in chromatin. In this report, we identify GATA1-bound distal sites genome-wide and find a global reorganization of the nucleosomes at these potential enhancers during differentiation of hematopoietic stem cells (HSCs) to erythrocytes. We show that the catalytic subunit BRG1 of BAF complexes localizes to these distal sites during differentiation and generates a longer nucleosome linker region surrounding the GATA1 sites by shifting the flanking nucleosomes away. Intriguingly, we find that the nucleosome shifting specifically facilitates binding of TAL1 but not GATA1 and is linked to subsequent transcriptional regulation of target genes. 
ER  -