TY - JOUR A1 - Perego, Ugo A. A1 - Angerhofer, Norman A1 - Pala, Maria A1 - Olivieri, Anna A1 - Lancioni, Hovirag A1 - Kashani, Baharak Hooshiar A1 - Carossa, Valeria A1 - Ekins, Jayne E. A1 - Gómez-Carballa, Alberto A1 - Huber, Gabriela A1 - Zimmermann, Bettina A1 - Corach, Daniel A1 - Babudri, Nora A1 - Panara, Fausto A1 - Myres, Natalie M. A1 - Parson, Walther A1 - Semino, Ornella A1 - Salas, Antonio A1 - Woodward, Scott R. A1 - Achilli, Alessandro A1 - Torroni, Antonio T1 - The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia Y1 - 2010/09/01 JF - Genome Research JO - Genome Research SP - 1174 EP - 1179 DO - 10.1101/gr.109231.110 VL - 20 IS - 9 UR - http://genome.cshlp.org/content/20/9/1174.abstract N2 - Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d—the third subset of C1—looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d. ER -