TY  - JOUR
A1  - Lin, Andy
A1  - Wang, Richard T.
A1  - Ahn, Sangtae
A1  - Park, Christopher C.
A1  - Smith, Desmond J.
T1  - A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes
Y1  - 2010/08/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1122 
EP  - 1132 
DO  - 10.1101/gr.104216.109 
VL  - 20 
IS  - 8 
UR  - http://genome.cshlp.org/content/20/8/1122.abstract 
N2  - Using radiation hybrid genotyping data, 99% of all possible gene pairs across the mammalian genome were tested for interactions based on co-retention frequencies higher (attraction) or lower (repulsion) than chance. Gene interaction networks constructed from six independent data sets overlapped strongly. Combining the data sets resulted in a network of more than seven million interactions, almost all attractive. This network overlapped with protein–protein interaction networks on multiple measures and also confirmed the relationship between essentiality and centrality. In contrast to other biological networks, the radiation hybrid network did not show a scale-free distribution of connectivity but was Gaussian-like, suggesting a closer approach to saturation. The radiation hybrid (RH) network constitutes a platform for understanding the systems biology of the mammalian cell. 
ER  -