TY  - JOUR
A1  - Zhang, Yong E.
A1  - Vibranovski, Maria D.
A1  - Krinsky, Benjamin H.
A1  - Long, Manyuan
T1  - Age-dependent chromosomal distribution of male-biased genes in Drosophila
Y1  - 2010/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1526 
EP  - 1533 
DO  - 10.1101/gr.107334.110 
VL  - 20 
IS  - 11 
UR  - http://genome.cshlp.org/content/20/11/1526.abstract 
N2  - We investigated the correlation between the chromosomal location and age distribution of new male-biased genes formed by duplications via DNA intermediates (DNA-level) or by de novo origination in Drosophila. Our genome-wide analysis revealed an excess of young X-linked male-biased genes. The proportion of X-linked male-biased genes then diminishes through time, leading to an autosomal excess of male-biased genes. The switch between X-linked and autosomal enrichment of male-biased genes was also present in the distribution of both protein-coding genes on the D. pseudoobscura neo-X chromosome and microRNA genes of D. melanogaster. These observations revealed that the evolution of male-biased genes is more complicated than the previously detected one-step X→A gene traffic and the enrichment of the male-biased genes on autosomes. The pattern we detected suggests that the interaction of various evolutionary forces such as the meiotic sex chromosome inactivation (MSCI), faster-X effect, and sexual antagonism in the male germline might have shaped the chromosomal distribution of male-biased genes on different evolutionary time scales. 
ER  -