TY  - JOUR
A1  - Weese, David
A1  - Emde, Anne-Katrin
A1  - Rausch, Tobias
A1  - Döring, Andreas
A1  - Reinert, Knut
T1  - RazerS—fast read mapping with sensitivity control
Y1  - 2009/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1646 
EP  - 1654 
DO  - 10.1101/gr.088823.108 
VL  - 19 
IS  - 9 
UR  - http://genome.cshlp.org/content/19/9/1646.abstract 
N2  - Second-generation sequencing technologies deliver DNA sequence data at unprecedented high throughput. Common to most biological applications is a mapping of the reads to an almost identical or highly similar reference genome. Due to the large amounts of data, efficient algorithms and implementations are crucial for this task. We present an efficient read mapping tool called RazerS. It allows the user to align sequencing reads of arbitrary length using either the Hamming distance or the edit distance. Our tool can work either lossless or with a user-defined loss rate at higher speeds. Given the loss rate, we present an approach that guarantees not to lose more reads than specified. This enables the user to adapt to the problem at hand and provides a seamless tradeoff between sensitivity and running time. 
ER  -