RT Journal
A1 Mak, H. Craig
A1 Pillus, Lorraine
A1 Ideker, Trey
T1 Dynamic reprogramming of transcription factors to and from the subtelomere
JF Genome Research 
JO Genome Research 
YR 2009 
FD June 01 
VO 19 
IS 6 
SP 1014 
OP 1025 
DO 10.1101/gr.084178.108 
UL http://genome.cshlp.org/content/19/6/1014.abstract 
AB Transcription factors are most commonly thought of as proteins that regulate expression of specific genes, independently of the order of those genes along the chromosome. By screening genome-wide chromatin immunoprecipitation (ChIP) profiles in yeast, we find that more than 10% of DNA-binding transcription factors concentrate at the subtelomeric regions near to chromosome ends. None of the proteins identified were previously implicated in regulation at telomeres, yet genomic and proteomic studies reveal that a subset of factors show many interactions with established telomere binding complexes. For many factors, the subtelomeric binding pattern is dynamic and undergoes flux toward or away from the telomere as physiological conditions shift. We find that subtelomeric binding is dependent on environmental conditions and correlates with the induction of gene expression in response to stress. Taken together, these results underscore the importance of genome structure in understanding the regulatory dynamics of transcriptional networks.