TY  - JOUR
A1  - Inagaki, Hidehito
A1  - Ohye, Tamae
A1  - Kogo, Hiroshi
A1  - Kato, Takema
A1  - Bolor, Hasbaira
A1  - Taniguchi, Mariko
A1  - Shaikh, Tamim H.
A1  - Emanuel, Beverly S.
A1  - Kurahashi, Hiroki
T1  - Chromosomal instability mediated by non-B DNA: Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans
Y1  - 2009/02/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 191 
EP  - 198 
DO  - 10.1101/gr.079244.108 
VL  - 19 
IS  - 2 
UR  - http://genome.cshlp.org/content/19/2/191.abstract 
N2  - Chromosomal aberrations have been thought to be random events. However, recent findings introduce a new paradigm in which certain DNA segments have the potential to adopt unusual conformations that lead to genomic instability and nonrandom chromosomal rearrangement. One of the best-studied examples is the palindromic AT-rich repeat (PATRR), which induces recurrent constitutional translocations in humans. Here, we established a plasmid-based model that promotes frequent intermolecular rearrangements between two PATRRs in HEK293 cells. In this model system, the proportion of PATRR plasmid that extrudes a cruciform structure correlates to the levels of rearrangement. Our data suggest that PATRR-mediated translocations are attributable to unusual DNA conformations that confer a common pathway for chromosomal rearrangements in humans. 
ER  -