@article{Inagaki01022009,
author = {Inagaki, Hidehito and Ohye, Tamae and Kogo, Hiroshi and Kato, Takema and Bolor, Hasbaira and Taniguchi, Mariko and Shaikh, Tamim H. and Emanuel, Beverly S. and Kurahashi, Hiroki}, 
title = {Chromosomal instability mediated by non-B DNA: Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans},
volume = {19}, 
number = {2}, 
pages = {191-198}, 
year = {2009}, 
doi = {10.1101/gr.079244.108}, 
abstract ={Chromosomal aberrations have been thought to be random events. However, recent findings introduce a new paradigm in which certain DNA segments have the potential to adopt unusual conformations that lead to genomic instability and nonrandom chromosomal rearrangement. One of the best-studied examples is the palindromic AT-rich repeat (PATRR), which induces recurrent constitutional translocations in humans. Here, we established a plasmid-based model that promotes frequent intermolecular rearrangements between two PATRRs in HEK293 cells. In this model system, the proportion of PATRR plasmid that extrudes a cruciform structure correlates to the levels of rearrangement. Our data suggest that PATRR-mediated translocations are attributable to unusual DNA conformations that confer a common pathway for chromosomal rearrangements in humans.}, 
URL = {http://genome.cshlp.org/content/19/2/191.abstract}, 
eprint = {http://genome.cshlp.org/content/19/2/191.full.pdf+html}, 
journal = {Genome Research} 
}