RT Journal A1 The NIH HMP Working Group A1 Peterson, Jane A1 Garges, Susan A1 Giovanni, Maria A1 McInnes, Pamela A1 Wang, Lu A1 Schloss, Jeffery A. A1 Bonazzi, Vivien A1 McEwen, Jean E. A1 Wetterstrand, Kris A. A1 Deal, Carolyn A1 Baker, Carl C. A1 Di Francesco, Valentina A1 Howcroft, T. Kevin A1 Karp, Robert W. A1 Lunsford, R. Dwayne A1 Wellington, Christopher R. A1 Belachew, Tsegahiwot A1 Wright, Michael A1 Giblin, Christina A1 David, Hagit A1 Mills, Melody A1 Salomon, Rachelle A1 Mullins, Christopher A1 Akolkar, Beena A1 Begg, Lisa A1 Davis, Cindy A1 Grandison, Lindsey A1 Humble, Michael A1 Khalsa, Jag A1 Little, A. Roger A1 Peavy, Hannah A1 Pontzer, Carol A1 Portnoy, Matthew A1 Sayre, Michael H. A1 Starke-Reed, Pamela A1 Zakhari, Samir A1 Read, Jennifer A1 Watson, Bracie A1 Guyer, Mark T1 The NIH Human Microbiome Project JF Genome Research JO Genome Research YR 2009 FD December 01 VO 19 IS 12 SP 2317 OP 2323 DO 10.1101/gr.096651.109 UL http://genome.cshlp.org/content/19/12/2317.abstract AB The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: (1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 “normal” volunteers; (2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and (3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here.