TY - JOUR A1 - The NIH HMP Working Group A1 - Peterson, Jane A1 - Garges, Susan A1 - Giovanni, Maria A1 - McInnes, Pamela A1 - Wang, Lu A1 - Schloss, Jeffery A. A1 - Bonazzi, Vivien A1 - McEwen, Jean E. A1 - Wetterstrand, Kris A. A1 - Deal, Carolyn A1 - Baker, Carl C. A1 - Di Francesco, Valentina A1 - Howcroft, T. Kevin A1 - Karp, Robert W. A1 - Lunsford, R. Dwayne A1 - Wellington, Christopher R. A1 - Belachew, Tsegahiwot A1 - Wright, Michael A1 - Giblin, Christina A1 - David, Hagit A1 - Mills, Melody A1 - Salomon, Rachelle A1 - Mullins, Christopher A1 - Akolkar, Beena A1 - Begg, Lisa A1 - Davis, Cindy A1 - Grandison, Lindsey A1 - Humble, Michael A1 - Khalsa, Jag A1 - Little, A. Roger A1 - Peavy, Hannah A1 - Pontzer, Carol A1 - Portnoy, Matthew A1 - Sayre, Michael H. A1 - Starke-Reed, Pamela A1 - Zakhari, Samir A1 - Read, Jennifer A1 - Watson, Bracie A1 - Guyer, Mark T1 - The NIH Human Microbiome Project Y1 - 2009/12/01 JF - Genome Research JO - Genome Research SP - 2317 EP - 2323 DO - 10.1101/gr.096651.109 VL - 19 IS - 12 UR - http://genome.cshlp.org/content/19/12/2317.abstract N2 - The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: (1) to take advantage of new, high-throughput technologies to characterize the human microbiome more fully by studying samples from multiple body sites from each of at least 250 “normal” volunteers; (2) to determine whether there are associations between changes in the microbiome and health/disease by studying several different medical conditions; and (3) to provide both a standardized data resource and new technological approaches to enable such studies to be undertaken broadly in the scientific community. The ethical, legal, and social implications of such research are being systematically studied as well. The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome. The history and implementation of this new program are described here. ER -