RT Journal
A1 The Génolevures Consortium
A1 Souciet, Jean-Luc
A1 Dujon, Bernard
A1 Gaillardin, Claude
A1 Johnston, Mark
A1 Baret, Philippe V.
A1 Cliften, Paul
A1 Sherman, David J.
A1 Weissenbach, Jean
A1 Westhof, Eric
A1 Wincker, Patrick
A1 Jubin, Claire
A1 Poulain, Julie
A1 Barbe, Valérie
A1 Ségurens, Béatrice
A1 Artiguenave, François
A1 Anthouard, Véronique
A1 Vacherie, Benoit
A1 Val, Marie-Eve
A1 Fulton, Robert S.
A1 Minx, Patrick
A1 Wilson, Richard
A1 Durrens, Pascal
A1 Jean, Géraldine
A1 Marck, Christian
A1 Martin, Tiphaine
A1 Nikolski, Macha
A1 Rolland, Thomas
A1 Seret, Marie-Line
A1 Casarégola, Serge
A1 Despons, Laurence
A1 Fairhead, Cécile
A1 Fischer, Gilles
A1 Lafontaine, Ingrid
A1 Leh, Véronique
A1 Lemaire, Marc
A1 de Montigny, Jacky
A1 Neuvéglise, Cécile
A1 Thierry, Agnès
A1 Blanc-Lenfle, Isabelle
A1 Bleykasten, Claudine
A1 Diffels, Julie
A1 Fritsch, Emilie
A1 Frangeul, Lionel
A1 Goëffon, Adrien
A1 Jauniaux, Nicolas
A1 Kachouri-Lafond, Rym
A1 Payen, Célia
A1 Potier, Serge
A1 Pribylova, Lenka
A1 Ozanne, Christophe
A1 Richard, Guy-Franck
A1 Sacerdot, Christine
A1 Straub, Marie-Laure
A1 Talla, Emmanuel
T1 Comparative genomics of protoploid Saccharomycetaceae
JF Genome Research 
JO Genome Research 
YR 2009 
FD October 01 
VO 19 
IS 10 
SP 1696 
OP 1709 
DO 10.1101/gr.091546.109 
UL http://genome.cshlp.org/content/19/10/1696.abstract 
AB Our knowledge of yeast genomes remains largely dominated by the extensive studies on Saccharomyces cerevisiae and the consequences of its ancestral duplication, leaving the evolution of the entire class of hemiascomycetes only partly explored. We concentrate here on five species of Saccharomycetaceae, a large subdivision of hemiascomycetes, that we call “protoploid” because they diverged from the S. cerevisiae lineage prior to its genome duplication. We determined the complete genome sequences of three of these species: Kluyveromyces (Lachancea) thermotolerans and Saccharomyces (Lachancea) kluyveri (two members of the newly described Lachancea clade), and Zygosaccharomyces rouxii. We included in our comparisons the previously available sequences of Kluyveromyces lactis and Ashbya (Eremothecium) gossypii. Despite their broad evolutionary range and significant individual variations in each lineage, the five protoploid Saccharomycetaceae share a core repertoire of approximately 3300 protein families and a high degree of conserved synteny. Synteny blocks were used to define gene orthology and to infer ancestors. Far from representing minimal genomes without redundancy, the five protoploid yeasts contain numerous copies of paralogous genes, either dispersed or in tandem arrays, that, altogether, constitute a third of each genome. Ancient, conserved paralogs as well as novel, lineage-specific paralogs were identified.