@article{The Génolevures Consortium01102009,
author = {The Génolevures Consortium and Souciet, Jean-Luc and Dujon, Bernard and Gaillardin, Claude and Johnston, Mark and Baret, Philippe V. and Cliften, Paul and Sherman, David J. and Weissenbach, Jean and Westhof, Eric and Wincker, Patrick and Jubin, Claire and Poulain, Julie and Barbe, Valérie and Ségurens, Béatrice and Artiguenave, François and Anthouard, Véronique and Vacherie, Benoit and Val, Marie-Eve and Fulton, Robert S. and Minx, Patrick and Wilson, Richard and Durrens, Pascal and Jean, Géraldine and Marck, Christian and Martin, Tiphaine and Nikolski, Macha and Rolland, Thomas and Seret, Marie-Line and Casarégola, Serge and Despons, Laurence and Fairhead, Cécile and Fischer, Gilles and Lafontaine, Ingrid and Leh, Véronique and Lemaire, Marc and de Montigny, Jacky and Neuvéglise, Cécile and Thierry, Agnès and Blanc-Lenfle, Isabelle and Bleykasten, Claudine and Diffels, Julie and Fritsch, Emilie and Frangeul, Lionel and Goëffon, Adrien and Jauniaux, Nicolas and Kachouri-Lafond, Rym and Payen, Célia and Potier, Serge and Pribylova, Lenka and Ozanne, Christophe and Richard, Guy-Franck and Sacerdot, Christine and Straub, Marie-Laure and Talla, Emmanuel}, 
title = {Comparative genomics of protoploid Saccharomycetaceae},
volume = {19}, 
number = {10}, 
pages = {1696-1709}, 
year = {2009}, 
doi = {10.1101/gr.091546.109}, 
abstract ={Our knowledge of yeast genomes remains largely dominated by the extensive studies on Saccharomyces cerevisiae and the consequences of its ancestral duplication, leaving the evolution of the entire class of hemiascomycetes only partly explored. We concentrate here on five species of Saccharomycetaceae, a large subdivision of hemiascomycetes, that we call “protoploid” because they diverged from the S. cerevisiae lineage prior to its genome duplication. We determined the complete genome sequences of three of these species: Kluyveromyces (Lachancea) thermotolerans and Saccharomyces (Lachancea) kluyveri (two members of the newly described Lachancea clade), and Zygosaccharomyces rouxii. We included in our comparisons the previously available sequences of Kluyveromyces lactis and Ashbya (Eremothecium) gossypii. Despite their broad evolutionary range and significant individual variations in each lineage, the five protoploid Saccharomycetaceae share a core repertoire of approximately 3300 protein families and a high degree of conserved synteny. Synteny blocks were used to define gene orthology and to infer ancestors. Far from representing minimal genomes without redundancy, the five protoploid yeasts contain numerous copies of paralogous genes, either dispersed or in tandem arrays, that, altogether, constitute a third of each genome. Ancient, conserved paralogs as well as novel, lineage-specific paralogs were identified.}, 
URL = {http://genome.cshlp.org/content/19/10/1696.abstract}, 
eprint = {http://genome.cshlp.org/content/19/10/1696.full.pdf+html}, 
journal = {Genome Research} 
}