RT Journal
A1 Johannesson, Martina
A1 Lopez-Aumatell, Regina
A1 Stridh, Pernilla
A1 Diez, Margarita
A1 Tuncel, Jonatan
A1 Blázquez, Gloria
A1 Martinez-Membrives, Esther
A1 Cañete, Toni
A1 Vicens-Costa, Elia
A1 Graham, Delyth
A1 Copley, Richard R.
A1 Hernandez-Pliego, Polinka
A1 Beyeen, Amennai D.
A1 Öckinger, Johan
A1 Fernández-Santamaría, Cristina
A1 Gulko, Percio S.
A1 Brenner, Max
A1 Tobeña, Adolf
A1 Guitart-Masip, Marc
A1 Giménez-Llort, Lydia
A1 Dominiczak, Anna
A1 Holmdahl, Rikard
A1 Gauguier, Dominique
A1 Olsson, Tomas
A1 Mott, Richard
A1 Valdar, William
A1 Redei, Eva E.
A1 Fernández-Teruel, Alberto
A1 Flint, Jonathan
T1 A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock
JF Genome Research 
JO Genome Research 
YR 2009 
FD January 01 
VO 19 
IS 1 
SP 150 
OP 158 
DO 10.1101/gr.081497.108 
UL http://genome.cshlp.org/content/19/1/150.abstract 
AB The laboratory rat (Rattus norvegicus) is a key tool for the study of medicine and pharmacology for human health. A large database of phenotypes for integrated fields such as cardiovascular, neuroscience, and exercise physiology exists in the literature. However, the molecular characterization of the genetic loci that give rise to variation in these traits has proven to be difficult. Here we show how one obstacle to progress, the fine-mapping of quantitative trait loci (QTL), can be overcome by using an outbred population of rats. By use of a genetically heterogeneous stock of rats, we map a locus contributing to variation in a fear-related measure (two-way active avoidance in the shuttle box) to a region on chromosome 5 containing nine genes. By establishing a protocol measuring multiple phenotypes including immunology, neuroinflammation, and hematology, as well as cardiovascular, metabolic, and behavioral traits, we establish the rat HS as a new resource for the fine-mapping of QTLs contributing to variation in complex traits of biomedical relevance.