TY  - JOUR
A1  - Johannesson, Martina
A1  - Lopez-Aumatell, Regina
A1  - Stridh, Pernilla
A1  - Diez, Margarita
A1  - Tuncel, Jonatan
A1  - Blázquez, Gloria
A1  - Martinez-Membrives, Esther
A1  - Cañete, Toni
A1  - Vicens-Costa, Elia
A1  - Graham, Delyth
A1  - Copley, Richard R.
A1  - Hernandez-Pliego, Polinka
A1  - Beyeen, Amennai D.
A1  - Öckinger, Johan
A1  - Fernández-Santamaría, Cristina
A1  - Gulko, Percio S.
A1  - Brenner, Max
A1  - Tobeña, Adolf
A1  - Guitart-Masip, Marc
A1  - Giménez-Llort, Lydia
A1  - Dominiczak, Anna
A1  - Holmdahl, Rikard
A1  - Gauguier, Dominique
A1  - Olsson, Tomas
A1  - Mott, Richard
A1  - Valdar, William
A1  - Redei, Eva E.
A1  - Fernández-Teruel, Alberto
A1  - Flint, Jonathan
T1  - A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock
Y1  - 2009/01/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 150 
EP  - 158 
DO  - 10.1101/gr.081497.108 
VL  - 19 
IS  - 1 
UR  - http://genome.cshlp.org/content/19/1/150.abstract 
N2  - The laboratory rat (Rattus norvegicus) is a key tool for the study of medicine and pharmacology for human health. A large database of phenotypes for integrated fields such as cardiovascular, neuroscience, and exercise physiology exists in the literature. However, the molecular characterization of the genetic loci that give rise to variation in these traits has proven to be difficult. Here we show how one obstacle to progress, the fine-mapping of quantitative trait loci (QTL), can be overcome by using an outbred population of rats. By use of a genetically heterogeneous stock of rats, we map a locus contributing to variation in a fear-related measure (two-way active avoidance in the shuttle box) to a region on chromosome 5 containing nine genes. By establishing a protocol measuring multiple phenotypes including immunology, neuroinflammation, and hematology, as well as cardiovascular, metabolic, and behavioral traits, we establish the rat HS as a new resource for the fine-mapping of QTLs contributing to variation in complex traits of biomedical relevance. 
ER  -