@article{Johannesson01012009,
author = {Johannesson, Martina and Lopez-Aumatell, Regina and Stridh, Pernilla and Diez, Margarita and Tuncel, Jonatan and Blázquez, Gloria and Martinez-Membrives, Esther and Cañete, Toni and Vicens-Costa, Elia and Graham, Delyth and Copley, Richard R. and Hernandez-Pliego, Polinka and Beyeen, Amennai D. and Öckinger, Johan and Fernández-Santamaría, Cristina and Gulko, Percio S. and Brenner, Max and Tobeña, Adolf and Guitart-Masip, Marc and Giménez-Llort, Lydia and Dominiczak, Anna and Holmdahl, Rikard and Gauguier, Dominique and Olsson, Tomas and Mott, Richard and Valdar, William and Redei, Eva E. and Fernández-Teruel, Alberto and Flint, Jonathan}, 
title = {A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock},
volume = {19}, 
number = {1}, 
pages = {150-158}, 
year = {2009}, 
doi = {10.1101/gr.081497.108}, 
abstract ={The laboratory rat (Rattus norvegicus) is a key tool for the study of medicine and pharmacology for human health. A large database of phenotypes for integrated fields such as cardiovascular, neuroscience, and exercise physiology exists in the literature. However, the molecular characterization of the genetic loci that give rise to variation in these traits has proven to be difficult. Here we show how one obstacle to progress, the fine-mapping of quantitative trait loci (QTL), can be overcome by using an outbred population of rats. By use of a genetically heterogeneous stock of rats, we map a locus contributing to variation in a fear-related measure (two-way active avoidance in the shuttle box) to a region on chromosome 5 containing nine genes. By establishing a protocol measuring multiple phenotypes including immunology, neuroinflammation, and hematology, as well as cardiovascular, metabolic, and behavioral traits, we establish the rat HS as a new resource for the fine-mapping of QTLs contributing to variation in complex traits of biomedical relevance.}, 
URL = {http://genome.cshlp.org/content/19/1/150.abstract}, 
eprint = {http://genome.cshlp.org/content/19/1/150.full.pdf+html}, 
journal = {Genome Research} 
}