RT Journal
A1 Rakyan, Vardhman K.
A1 Down, Thomas A.
A1 Thorne, Natalie P.
A1 Flicek, Paul
A1 Kulesha, Eugene
A1 Gräf, Stefan
A1 Tomazou, Eleni M.
A1 Bäckdahl, Liselotte
A1 Johnson, Nathan
A1 Herberth, Marlis
A1 Howe, Kevin L.
A1 Jackson, David K.
A1 Miretti, Marcos M.
A1 Fiegler, Heike
A1 Marioni, John C.
A1 Birney, Ewan
A1 Hubbard, Tim J.P.
A1 Carter, Nigel P.
A1 Tavaré, Simon
A1 Beck, Stephan
T1 An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)
JF Genome Research 
JO Genome Research 
YR 2008 
FD September 01 
VO 18 
IS 9 
SP 1518 
OP 1529 
DO 10.1101/gr.077479.108 
UL http://genome.cshlp.org/content/18/9/1518.abstract 
AB We report a novel resource (methylation profiles of DNA, or mPod) for human genome-wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts, genome-wide DNA methylation reference profiles of 13 normal somatic tissues, placenta, sperm, and an immortalized cell line, a visualization tool that has been integrated with the Ensembl genome browser and a new algorithm for the analysis of immunoprecipitation-based DNA methylation profiles. We demonstrate the utility of our resource by identifying the first comprehensive genome-wide set of tissue-specific differentially methylated regions (tDMRs) that may play a role in cellular identity and the regulation of tissue-specific genome function. We also discuss the implications of our findings with respect to the regulatory potential of regions with varied CpG density, gene expression, transcription factor motifs, gene ontology, and correlation with other epigenetic marks such as histone modifications.