TY  - JOUR
A1  - Rakyan, Vardhman K.
A1  - Down, Thomas A.
A1  - Thorne, Natalie P.
A1  - Flicek, Paul
A1  - Kulesha, Eugene
A1  - Gräf, Stefan
A1  - Tomazou, Eleni M.
A1  - Bäckdahl, Liselotte
A1  - Johnson, Nathan
A1  - Herberth, Marlis
A1  - Howe, Kevin L.
A1  - Jackson, David K.
A1  - Miretti, Marcos M.
A1  - Fiegler, Heike
A1  - Marioni, John C.
A1  - Birney, Ewan
A1  - Hubbard, Tim J.P.
A1  - Carter, Nigel P.
A1  - Tavaré, Simon
A1  - Beck, Stephan
T1  - An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)
Y1  - 2008/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1518 
EP  - 1529 
DO  - 10.1101/gr.077479.108 
VL  - 18 
IS  - 9 
UR  - http://genome.cshlp.org/content/18/9/1518.abstract 
N2  - We report a novel resource (methylation profiles of DNA, or mPod) for human genome-wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts, genome-wide DNA methylation reference profiles of 13 normal somatic tissues, placenta, sperm, and an immortalized cell line, a visualization tool that has been integrated with the Ensembl genome browser and a new algorithm for the analysis of immunoprecipitation-based DNA methylation profiles. We demonstrate the utility of our resource by identifying the first comprehensive genome-wide set of tissue-specific differentially methylated regions (tDMRs) that may play a role in cellular identity and the regulation of tissue-specific genome function. We also discuss the implications of our findings with respect to the regulatory potential of regions with varied CpG density, gene expression, transcription factor motifs, gene ontology, and correlation with other epigenetic marks such as histone modifications. 
ER  -