TY  - JOUR
A1  - Jiang, Huifeng
A1  - Guan, Wenjun
A1  - Pinney, David
A1  - Wang, Wen
A1  - Gu, Zhenglong
T1  - Relaxation of yeast mitochondrial functions after whole-genome duplication
Y1  - 2008/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1466 
EP  - 1471 
DO  - 10.1101/gr.074674.107 
VL  - 18 
IS  - 9 
UR  - http://genome.cshlp.org/content/18/9/1466.abstract 
N2  - Mitochondria are essential for cellular energy production in most eukaryotic organisms. However, when glucose is abundant, yeast species that underwent whole-genome duplication (WGD) mostly conduct fermentation even under aerobic conditions, and most can survive without a functional mitochondrial genome. In this study, we show that the rate of evolution for the nuclear-encoded mitochondrial genes was greater in post-WGD species than pre-WGD species. Furthermore, codon usage bias was relaxed for these genes in post-WGD yeast species. The codon usage pattern and the distribution of a particular transcription regulatory element suggest that the change to an efficient aerobic fermentation lifestyle in this lineage might have emerged after WGD between the divergence of Kluyveromyces polysporus and Saccharomyces castellii from their common ancestor. This new energy production strategy could have led to the relaxation of mitochondrial function in the relevant yeast species. 
ER  -