RT Journal
A1 Studer, Romain A.
A1 Penel, Simon
A1 Duret, Laurent
A1 Robinson-Rechavi, Marc
T1 Pervasive positive selection on duplicated and nonduplicated vertebrate protein coding genes
JF Genome Research 
JO Genome Research 
YR 2008 
FD September 01 
VO 18 
IS 9 
SP 1393 
OP 1402 
DO 10.1101/gr.076992.108 
UL http://genome.cshlp.org/content/18/9/1393.abstract 
AB A stringent branch-site codon model was used to detect positive selection in vertebrate evolution. We show that the test is robust to the large evolutionary distances involved. Positive selection was detected in 77% of 884 genes studied. Most positive selection concerns a few sites on a single branch of the phylogenetic tree: Between 0.9% and 4.7% of sites are affected by positive selection depending on the branches. No functional category was overrepresented among genes under positive selection. Surprisingly, whole genome duplication had no effect on the prevalence of positive selection, whether the fish-specific genome duplication or the two rounds at the origin of vertebrates. Thus positive selection has not been limited to a few gene classes, or to specific evolutionary events such as duplication, but has been pervasive during vertebrate evolution.