RT Journal
A1 Ideker, Trey
A1 Sharan, Roded
T1 Protein networks in disease
JF Genome Research 
JO Genome Research 
YR 2008 
FD April 01 
VO 18 
IS 4 
SP 644 
OP 652 
DO 10.1101/gr.071852.107 
UL http://genome.cshlp.org/content/18/4/644.abstract 
AB During a decade of proof-of-principle analysis in model organisms, protein networks have been used to further the study of molecular evolution, to gain insight into the robustness of cells to perturbation, and for assignment of new protein functions. Following these analyses, and with the recent rise of protein interaction measurements in mammals, protein networks are increasingly serving as tools to unravel the molecular basis of disease. We review promising applications of protein networks to disease in four major areas: identifying new disease genes; the study of their network properties; identifying disease-related subnetworks; and network-based disease classification. Applications in infectious disease, personalized medicine, and pharmacology are also forthcoming as the available protein network information improves in quality and coverage.