TY  - JOUR
A1  - Cordero, Otto X.
A1  - Snel, Berend
A1  - Hogeweg, Paulien
T1  - Coevolution of gene families in prokaryotes
Y1  - 2008/03/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 462 
EP  - 468 
DO  - 10.1101/gr.6815508 
VL  - 18 
IS  - 3 
UR  - http://genome.cshlp.org/content/18/3/462.abstract 
N2  - We study gene family coevolution on a tree of life based on a large-scale ancestral gene content reconstruction, which includes gene duplication and deletion events. The insights obtained from this study are threefold: (1) Global properties, such as the distribution of coevolution partners and the formation of disconnected clusters of coevolving families, can be an inevitable consequence of evolution along a tree. (2) Concerted family expansion (gene duplication) and contraction (gene deletion) reflect functional constraints and therefore lead to better function prediction. (3) “Long-range” coevolutionary relationships, caused mostly by large family expansions or contractions, reveal high-level evolutionary organization of cellular processes in prokaryotes. 
ER  -