@article{Nagy01122008,
author = {Nagy, Ervin D. and Bennetzen, Jeffrey L.}, 
title = {Pathogen corruption and site-directed recombination at a plant disease resistance gene cluster},
volume = {18}, 
number = {12}, 
pages = {1918-1923}, 
year = {2008}, 
doi = {10.1101/gr.078766.108}, 
abstract ={The Pc locus of sorghum (Sorghum bicolor) determines dominant sensitivity to a host-selective toxin produced by the fungal pathogen Periconia circinata. The Pc region was cloned by a map-based approach and found to contain three tandemly repeated genes with the structures of nucleotide binding site–leucine-rich repeat (NBS–LRR) disease resistance genes. Thirteen independent Pc-to-pc mutations were analyzed, and each was found to remove all or part of the central gene of the threesome. Hence, this central gene is Pc. Most Pc-to-pc mutations were associated with unequal recombination. Eight recombination events were localized to different sites in a 560-bp region within the ∼3.7-kb NBS–LRR genes. Because any unequal recombination located within the flanking NBS–LRR genes would have removed Pc, the clustering of cross-over events within a 560-bp segment indicates that a site-directed recombination process exists that specifically targets unequal events to generate LRR diversity in NBS–LRR loci.}, 
URL = {http://genome.cshlp.org/content/18/12/1918.abstract}, 
eprint = {http://genome.cshlp.org/content/18/12/1918.full.pdf+html}, 
journal = {Genome Research} 
}