RT Journal
A1 Ottaviani, Diego
A1 Lever, Elliott
A1 Mitter, Richard
A1 Jones, Tania
A1 Forshew, Tim
A1 Christova, Rossitza
A1 Tomazou, Eleni M.
A1 Rakyan, Vardhman K.
A1 Krawetz, Stephen A.
A1 Platts, Adrian E.
A1 Segarane, Badmavady
A1 Beck, Stephan
A1 Sheer, Denise
T1 Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex
JF Genome Research 
JO Genome Research 
YR 2008 
FD November 01 
VO 18 
IS 11 
SP 1778 
OP 1786 
DO 10.1101/gr.082313.108 
UL http://genome.cshlp.org/content/18/11/1778.abstract 
AB The folding of chromatin into topologically constrained loop domains is essential for genomic function. We have identified genomic anchors that define the organization of chromatin loop domains across the human major histocompatibility complex (MHC). This locus contains critical genes for immunity and is associated with more diseases than any other region of the genome. Classical MHC genes are expressed in a cell type-specific pattern and can be induced by cytokines such as interferon-gamma (IFNG). Transcriptional activation of the MHC was associated with a reconfiguration of chromatin architecture resulting from the formation of additional genomic anchors. These findings suggest that the dynamic arrangement of genomic anchors and loops plays a role in transcriptional regulation.