TY  - JOUR
A1  - Ottaviani, Diego
A1  - Lever, Elliott
A1  - Mitter, Richard
A1  - Jones, Tania
A1  - Forshew, Tim
A1  - Christova, Rossitza
A1  - Tomazou, Eleni M.
A1  - Rakyan, Vardhman K.
A1  - Krawetz, Stephen A.
A1  - Platts, Adrian E.
A1  - Segarane, Badmavady
A1  - Beck, Stephan
A1  - Sheer, Denise
T1  - Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex
Y1  - 2008/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1778 
EP  - 1786 
DO  - 10.1101/gr.082313.108 
VL  - 18 
IS  - 11 
UR  - http://genome.cshlp.org/content/18/11/1778.abstract 
N2  - The folding of chromatin into topologically constrained loop domains is essential for genomic function. We have identified genomic anchors that define the organization of chromatin loop domains across the human major histocompatibility complex (MHC). This locus contains critical genes for immunity and is associated with more diseases than any other region of the genome. Classical MHC genes are expressed in a cell type-specific pattern and can be induced by cytokines such as interferon-gamma (IFNG). Transcriptional activation of the MHC was associated with a reconfiguration of chromatin architecture resulting from the formation of additional genomic anchors. These findings suggest that the dynamic arrangement of genomic anchors and loops plays a role in transcriptional regulation. 
ER  -