RT Journal
A1 Thomson, Nicholas R.
A1 Clayton, Debra J.
A1 Windhorst, Daniel
A1 Vernikos, Georgios
A1 Davidson, Susanne
A1 Churcher, Carol
A1 Quail, Michael A.
A1 Stevens, Mark
A1 Jones, Michael A.
A1 Watson, Michael
A1 Barron, Andy
A1 Layton, Abigail
A1 Pickard, Derek
A1 Kingsley, Robert A.
A1 Bignell, Alex
A1 Clark, Louise
A1 Harris, Barbara
A1 Ormond, Doug
A1 Abdellah, Zahra
A1 Brooks, Karen
A1 Cherevach, Inna
A1 Chillingworth, Tracey
A1 Woodward, John
A1 Norberczak, Halina
A1 Lord, Angela
A1 Arrowsmith, Claire
A1 Jagels, Kay
A1 Moule, Sharon
A1 Mungall, Karen
A1 Sanders, Mandy
A1 Whitehead, Sally
A1 Chabalgoity, Jose A.
A1 Maskell, Duncan
A1 Humphrey, Tom
A1 Roberts, Mark
A1 Barrow, Paul A.
A1 Dougan, Gordon
A1 Parkhill, Julian
T1 Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways
JF Genome Research 
JO Genome Research 
YR 2008 
FD October 01 
VO 18 
IS 10 
SP 1624 
OP 1637 
DO 10.1101/gr.077404.108 
UL http://genome.cshlp.org/content/18/10/1624.abstract 
AB We have determined the complete genome sequences of a host-promiscuous Salmonella enterica serovar Enteritidis PT4 isolate P125109 and a chicken-restricted Salmonella enterica serovar Gallinarum isolate 287/91. Genome comparisons between these and other Salmonella isolates indicate that S. Gallinarum 287/91 is a recently evolved descendent of S. Enteritidis. Significantly, the genome of S. Gallinarum has undergone extensive degradation through deletion and pseudogene formation. Comparison of the pseudogenes in S. Gallinarum with those identified previously in other host-adapted bacteria reveals the loss of many common functional traits and provides insights into possible mechanisms of host and tissue adaptation. We propose that experimental analysis in chickens and mice of S. Enteritidis–harboring mutations in functional homologs of the pseudogenes present in S. Gallinarum could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica.