TY  - JOUR
A1  - Thomson, Nicholas R.
A1  - Clayton, Debra J.
A1  - Windhorst, Daniel
A1  - Vernikos, Georgios
A1  - Davidson, Susanne
A1  - Churcher, Carol
A1  - Quail, Michael A.
A1  - Stevens, Mark
A1  - Jones, Michael A.
A1  - Watson, Michael
A1  - Barron, Andy
A1  - Layton, Abigail
A1  - Pickard, Derek
A1  - Kingsley, Robert A.
A1  - Bignell, Alex
A1  - Clark, Louise
A1  - Harris, Barbara
A1  - Ormond, Doug
A1  - Abdellah, Zahra
A1  - Brooks, Karen
A1  - Cherevach, Inna
A1  - Chillingworth, Tracey
A1  - Woodward, John
A1  - Norberczak, Halina
A1  - Lord, Angela
A1  - Arrowsmith, Claire
A1  - Jagels, Kay
A1  - Moule, Sharon
A1  - Mungall, Karen
A1  - Sanders, Mandy
A1  - Whitehead, Sally
A1  - Chabalgoity, Jose A.
A1  - Maskell, Duncan
A1  - Humphrey, Tom
A1  - Roberts, Mark
A1  - Barrow, Paul A.
A1  - Dougan, Gordon
A1  - Parkhill, Julian
T1  - Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways
Y1  - 2008/10/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1624 
EP  - 1637 
DO  - 10.1101/gr.077404.108 
VL  - 18 
IS  - 10 
UR  - http://genome.cshlp.org/content/18/10/1624.abstract 
N2  - We have determined the complete genome sequences of a host-promiscuous Salmonella enterica serovar Enteritidis PT4 isolate P125109 and a chicken-restricted Salmonella enterica serovar Gallinarum isolate 287/91. Genome comparisons between these and other Salmonella isolates indicate that S. Gallinarum 287/91 is a recently evolved descendent of S. Enteritidis. Significantly, the genome of S. Gallinarum has undergone extensive degradation through deletion and pseudogene formation. Comparison of the pseudogenes in S. Gallinarum with those identified previously in other host-adapted bacteria reveals the loss of many common functional traits and provides insights into possible mechanisms of host and tissue adaptation. We propose that experimental analysis in chickens and mice of S. Enteritidis–harboring mutations in functional homologs of the pseudogenes present in S. Gallinarum could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica. 
ER  -