@article{Thomson01102008,
author = {Thomson, Nicholas R. and Clayton, Debra J. and Windhorst, Daniel and Vernikos, Georgios and Davidson, Susanne and Churcher, Carol and Quail, Michael A. and Stevens, Mark and Jones, Michael A. and Watson, Michael and Barron, Andy and Layton, Abigail and Pickard, Derek and Kingsley, Robert A. and Bignell, Alex and Clark, Louise and Harris, Barbara and Ormond, Doug and Abdellah, Zahra and Brooks, Karen and Cherevach, Inna and Chillingworth, Tracey and Woodward, John and Norberczak, Halina and Lord, Angela and Arrowsmith, Claire and Jagels, Kay and Moule, Sharon and Mungall, Karen and Sanders, Mandy and Whitehead, Sally and Chabalgoity, Jose A. and Maskell, Duncan and Humphrey, Tom and Roberts, Mark and Barrow, Paul A. and Dougan, Gordon and Parkhill, Julian}, 
title = {Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways},
volume = {18}, 
number = {10}, 
pages = {1624-1637}, 
year = {2008}, 
doi = {10.1101/gr.077404.108}, 
abstract ={We have determined the complete genome sequences of a host-promiscuous Salmonella enterica serovar Enteritidis PT4 isolate P125109 and a chicken-restricted Salmonella enterica serovar Gallinarum isolate 287/91. Genome comparisons between these and other Salmonella isolates indicate that S. Gallinarum 287/91 is a recently evolved descendent of S. Enteritidis. Significantly, the genome of S. Gallinarum has undergone extensive degradation through deletion and pseudogene formation. Comparison of the pseudogenes in S. Gallinarum with those identified previously in other host-adapted bacteria reveals the loss of many common functional traits and provides insights into possible mechanisms of host and tissue adaptation. We propose that experimental analysis in chickens and mice of S. Enteritidis–harboring mutations in functional homologs of the pseudogenes present in S. Gallinarum could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in S. enterica.}, 
URL = {http://genome.cshlp.org/content/18/10/1624.abstract}, 
eprint = {http://genome.cshlp.org/content/18/10/1624.full.pdf+html}, 
journal = {Genome Research} 
}