TY  - JOUR
A1  - Thomson, Nicholas R.
A1  - Holden, Matthew T.G.
A1  - Carder, Caroline
A1  - Lennard, Nicola
A1  - Lockey, Sarah J.
A1  - Marsh, Pete
A1  - Skipp, Paul
A1  - O’Connor, C. David
A1  - Goodhead, Ian
A1  - Norbertzcak, Halina
A1  - Harris, Barbara
A1  - Ormond, Doug
A1  - Rance, Richard
A1  - Quail, Michael A.
A1  - Parkhill, Julian
A1  - Stephens, Richard S.
A1  - Clarke, Ian N.
T1  - Chlamydia trachomatis: Genome sequence analysis of lymphogranuloma venereum isolates
Y1  - 2008/01/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 161 
EP  - 171 
DO  - 10.1101/gr.7020108 
VL  - 18 
IS  - 1 
UR  - http://genome.cshlp.org/content/18/1/161.abstract 
N2  - Chlamydia trachomatis is the most common cause of sexually transmitted infections in the UK, a statistic that is also reflected globally. There are three biovariants of C. trachomatis: trachoma (serotypes A–C) and two sexually transmitted pathovars; serotypes D–K and lyphogranuloma venereum (LGV). Trachoma isolates and the sexually transmitted serotypes D–K are noninvasive, whereas the LGV strains are invasive, causing a disseminating infection of the local draining lymph nodes. Genome sequences are available for single isolates from the trachoma (serotype A) and sexually transmitted (serotype D) biotypes. We sequenced two isolates from the remaining biotype, LGV, a long-term laboratory passaged strain and the recent “epidemic” LGV isolate-causing proctitis. Although the genome of the LGV strain shows no additional genes that could account for the differences in disease outcome, we found evidence of functional gene loss and identified regions of heightened sequence variation that have previously been shown to be important sites for interstrain recombination. We have used new sequencing technologies to show that the recent clinical LGV isolate causing proctitis is unlikely to be a newly emerged strain but is most probably an old strain with relatively new clinical manifestations. 
ER  -