TY  - JOUR
A1  - Lin, Jimmy
A1  - Gan, Christine M.
A1  - Zhang, Xiaosong
A1  - Jones, Siân
A1  - Sjöblom, Tobias
A1  - Wood, Laura D.
A1  - Parsons, D. Williams
A1  - Papadopoulos, Nickolas
A1  - Kinzler, Kenneth W.
A1  - Vogelstein, Bert
A1  - Parmigiani, Giovanni
A1  - Velculescu, Victor E.
T1  - A multidimensional analysis of genes mutated in breast and colorectal cancers
Y1  - 2007/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1304 
EP  - 1318 
DO  - 10.1101/gr.6431107 
VL  - 17 
IS  - 9 
UR  - http://genome.cshlp.org/content/17/9/1304.abstract 
N2  - A recent study of a large number of genes in a panel of breast and colorectal cancers identified somatic mutations in 1149 genes. To identify potential biological processes affected by these genes, we examined their putative roles based on sequence similarity, membership in known functional groups and pathways, and predicted interactions with other proteins. These analyses identified functional groups and pathways that were enriched for mutated genes in both tumor types. Additionally, the results pointed to differences in molecular mechanisms that underlie breast and colorectal cancers, including various intracellular signaling and metabolic pathways. These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention. 
ER  -