TY  - JOUR
A1  - Garg, Kavita
A1  - Green, Phil
T1  - Differing patterns of selection in alternative and constitutive splice sites
Y1  - 2007/07/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1015 
EP  - 1022 
DO  - 10.1101/gr.6347907 
VL  - 17 
IS  - 7 
UR  - http://genome.cshlp.org/content/17/7/1015.abstract 
N2  - In addition to allowing identification of putative functional elements as regions having reduced substitution rates, comparison of genome sequences can also provide insights into these elements at the nucleotide level, by indicating the pattern of tolerated substitutions. We created data sets of orthologous alternative and constitutive splice sites in mouse, rat, and human and analyzed the substitutions occurring within them. Our results illuminate differences between alternative and constitutive sites and, in particular, strongly support the idea that alternative sites are under selection to be weak. 
ER  -