@article{Greenbaum01062007,
author = {Greenbaum, Jason A. and Pang, Bo and Tullius, Thomas D.}, 
title = {Construction of a genome-scale structural map at single-nucleotide resolution},
volume = {17}, 
number = {6}, 
pages = {947-953}, 
year = {2007}, 
doi = {10.1101/gr.6073107}, 
abstract ={Few methods are available for mapping the local structure of DNA throughout a genome. The hydroxyl radical cleavage pattern is a measure of the local variation in solvent-accessible surface area of duplex DNA, and thus provides information on the local shape and structure of DNA. We report the construction of a relational database, ORChID (OH Radical Cleavage Intensity Database), that contains extensive hydroxyl radical cleavage data produced from two DNA libraries. We have used the ORChID database to develop a set of algorithms that are capable of predicting the hydroxyl radical cleavage pattern of a DNA sequence of essentially any length, to high accuracy. We have used the prediction algorithm to produce a structural map of the 30 Mb of the ENCODE regions of the human genome.}, 
URL = {http://genome.cshlp.org/content/17/6/947.abstract}, 
eprint = {http://genome.cshlp.org/content/17/6/947.full.pdf+html}, 
journal = {Genome Research} 
}