RT Journal
A1 Bollenbach, Tobias
A1 Vetsigian, Kalin
A1 Kishony, Roy
T1 Evolution and multilevel optimization of the genetic code
JF Genome Research 
JO Genome Research 
YR 2007 
FD April 01 
VO 17 
IS 4 
SP 401 
OP 404 
DO 10.1101/gr.6144007 
UL http://genome.cshlp.org/content/17/4/401.abstract 
AB The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors.