RT Journal
A1 Ling, King-Hwa
A1 Rajandream, Marie-Adele
A1 Rivailler, Pierre
A1 Ivens, Alasdair
A1 Yap, Soon-Joo
A1 Madeira, Alda M.B.N.
A1 Mungall, Karen
A1 Billington, Karen
A1 Yee, Wai-Yan
A1 Bankier, Alan T.
A1 Carroll, Fionnadh
A1 Durham, Alan M.
A1 Peters, Nicholas
A1 Loo, Shu-San
A1 Mat Isa, Mohd Noor
A1 Novaes, Jeniffer
A1 Quail, Michael
A1 Rosli, Rozita
A1 Nor Shamsudin, Mariana
A1 Sobreira, Tiago J.P.
A1 Tivey, Adrian R.
A1 Wai, Siew-Fun
A1 White, Sarah
A1 Wu, Xikun
A1 Kerhornou, Arnaud
A1 Blake, Damer
A1 Mohamed, Rahmah
A1 Shirley, Martin
A1 Gruber, Arthur
A1 Berriman, Matthew
A1 Tomley, Fiona
A1 Dear, Paul H.
A1 Wan, Kiew-Lian
T1 Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization
JF Genome Research 
JO Genome Research 
YR 2007 
FD March 01 
VO 17 
IS 3 
SP 311 
OP 319 
DO 10.1101/gr.5823007 
UL http://genome.cshlp.org/content/17/3/311.abstract 
AB Eimeria tenella is an intracellular protozoan parasite that infects the intestinal tracts of domestic fowl and causes coccidiosis, a serious and sometimes lethal enteritis. Eimeria falls in the same phylum (Apicomplexa) as several human and animal parasites such as Cryptosporidium, Toxoplasma, and the malaria parasite, Plasmodium. Here we report the sequencing and analysis of the first chromosome of E. tenella, a chromosome believed to carry loci associated with drug resistance and known to differ between virulent and attenuated strains of the parasite. The chromosome—which appears to be representative of the genome—is gene-dense and rich in simple-sequence repeats, many of which appear to give rise to repetitive amino acid tracts in the predicted proteins. Most striking is the segmentation of the chromosome into repeat-rich regions peppered with transposon-like elements and telomere-like repeats, alternating with repeat-free regions. Predicted genes differ in character between the two types of segment, and the repeat-rich regions appear to be associated with strain-to-strain variation.