TY  - JOUR
A1  - Pontius, Joan U.
A1  - Mullikin, James C.
A1  - Smith, Douglas R.
A1  - Agencourt Sequencing Team
A1  - Lindblad-Toh, Kerstin
A1  - Gnerre, Sante
A1  - Clamp, Michele
A1  - Chang, Jean
A1  - Stephens, Robert
A1  - Neelam, Beena
A1  - Volfovsky, Natalia
A1  - Schäffer, Alejandro A.
A1  - Agarwala, Richa
A1  - Narfström, Kristina
A1  - Murphy, William J.
A1  - Giger, Urs
A1  - Roca, Alfred L.
A1  - Antunes, Agostinho
A1  - Menotti-Raymond, Marilyn
A1  - Yuhki, Naoya
A1  - Pecon-Slattery, Jill
A1  - Johnson, Warren E.
A1  - Bourque, Guillaume
A1  - Tesler, Glenn
A1  - NISC Comparative Sequencing Program
A1  - O’Brien, Stephen J.
T1  - Initial sequence and comparative analysis of the cat genome
Y1  - 2007/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1675 
EP  - 1689 
DO  - 10.1101/gr.6380007 
VL  - 17 
IS  - 11 
UR  - http://genome.cshlp.org/content/17/11/1675.abstract 
N2  - The genome sequence (1.9-fold coverage) of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals (human, chimpanzee, mouse, rat, dog, and cow). The results resolved chromosomal positions for 663,480 contigs, 20,285 putative feline gene orthologs, and 133,499 conserved sequence blocks (CSBs). Additional annotated features include repetitive elements, endogenous retroviral sequences, nuclear mitochondrial (numt) sequences, micro-RNAs, and evolutionary breakpoints that suggest historic balancing of translocation and inversion incidences in distinct mammalian lineages. Large numbers of single nucleotide polymorphisms (SNPs), deletion insertion polymorphisms (DIPs), and short tandem repeats (STRs), suitable for linkage or association studies were characterized in the context of long stretches of chromosome homozygosity. In spite of the light coverage capturing ∼65% of euchromatin sequence from the cat genome, these comparative insights shed new light on the tempo and mode of gene/genome evolution in mammals, promise several research applications for the cat, and also illustrate that a comparative approach using more deeply covered mammals provides an informative, preliminary annotation of a light (1.9-fold) coverage mammal genome sequence. 
ER  -