TY  - JOUR
A1  - Wirth, Thierry
A1  - Morelli, Giovanna
A1  - Kusecek, Barica
A1  - van Belkum, Alex
A1  - van der Schee, Cindy
A1  - Meyer, Axel
A1  - Achtman, Mark
T1  - The rise and spread of a new pathogen: Seroresistant Moraxella catarrhalis
Y1  - 2007/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1647 
EP  - 1656 
DO  - 10.1101/gr.6122607 
VL  - 17 
IS  - 11 
UR  - http://genome.cshlp.org/content/17/11/1647.abstract 
N2  - The nosocomial human pathogen Moraxella catarrhalis is one the most important agents of human respiratory tract infections. This species is composed of two distinct lineages, one of only moderate virulence, the so-called serosensitive subpopulation, and a second, the seroresistant one, which is enriched among strains that harbor two major virulence traits: complement resistance and adherence to epithelial cells. Using a suite of population genetics tools, we show that the seroresistant lineage is also characterized by higher homologous recombination and mutation rates at housekeeping genes relative to its less pathogenic counterpart. Thus, sex and virulence have evolved in tandem in M. catarrhalis. Moreover, phylogenetic and Bayesian analyses that take into account recombination between the two clades show that the ancestral group was avirulent, is possibly 70 million years old, and must have infected mammals prior to the evolution of humans, which occurred later. The younger seroresistant isolates went through an important population expansion some 5 million years ago, coincident with the hominid expansion. This rise and spread was possibly coupled with a host shift and the acquisition of virulence genes. 
ER  -