@article{Kondo01072006,
author = {Kondo, Mariko and Hornung, Ute and Nanda, Indrajit and Imai, Shuichiro and Sasaki, Takashi and Shimizu, Atsushi and Asakawa, Shuichi and Hori, Hiroshi and Schmid, Michael and Shimizu, Nobuyoshi and Schartl, Manfred}, 
title = {Genomic organization of the sex-determining and adjacent regions of the sex chromosomes of medaka},
volume = {16}, 
number = {7}, 
pages = {815-826}, 
year = {2006}, 
doi = {10.1101/gr.5016106}, 
abstract ={Sequencing of the human Y chromosome has uncovered the peculiarities of the genomic organization of a heterogametic sex chromosome of old evolutionary age, and has led to many insights into the evolutionary changes that occurred during its long history. We have studied the genomic organization of the medaka fish Y chromosome, which is one of the youngest heterogametic sex chromosomes on which molecular data are available. The Y specific and adjacent regions were sequenced and compared to the X. The male sex-determining gene, dmrt1bY, appears to be the only functional gene in the Y-specific region. The Y-specific region itself is derived from the duplication of a 43-kb fragment from linkage group 9. All other coduplicated genes except dmrt1bY degenerated. The Y-specific region has accumulated large stretches of repetitive sequences and duplicated pieces of DNA from elsewhere in the genome, thereby growing to 258 kb. Interestingly the non-recombining part of the Y did not spread out considerably from the original duplicated fragment, possibly because of a large sequence duplication bordering the Y-specific fragment. This may have conserved the more ancestral structure of the medaka Y and provides insights into some of the initial processes of Y chromosome evolution.}, 
URL = {http://genome.cshlp.org/content/16/7/815.abstract}, 
eprint = {http://genome.cshlp.org/content/16/7/815.full.pdf+html}, 
journal = {Genome Research} 
}