TY  - JOUR
A1  - Elnitski, Laura
A1  - Jin, Victor X.
A1  - Farnham, Peggy J.
A1  - Jones, Steven J.M.
T1  - Locating mammalian transcription factor binding sites: A survey of computational and experimental techniques
Y1  - 2006/12/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1455 
EP  - 1464 
DO  - 10.1101/gr.4140006 
VL  - 16 
IS  - 12 
UR  - http://genome.cshlp.org/content/16/12/1455.abstract 
N2  - Fields such as genomics and systems biology are built on the synergism between computational and experimental techniques. This type of synergism is especially important in accomplishing goals like identifying all functional transcription factor binding sites in vertebrate genomes. Precise detection of these elements is a prerequisite to deciphering the complex regulatory networks that direct tissue specific and lineage specific patterns of gene expression. This review summarizes approaches for in silico, in vitro, and in vivo identification of transcription factor binding sites. A variety of techniques useful for localized- and high-throughput analyses are discussed here, with emphasis on aspects of data generation and verification. 
ER  -